| 1 | Toyne/Holton/Garcia/Zuluaga (State) | 43.17 | 2016 | |
| 2 | Palomino/Lind/Cosentino/Panek-Kravitz | 43.25 | 2019 | |
| 3 | Toyne/Knecht/Lind/Panek-Kravitz | 43.32 | 2018 | |
| 4 | Palomino/Upchurch/Cossentino/Lind | 43.98 | 2020 | |
| 5 | Palomino/Knecht /Lind /Panek-Kravitz | 43.42 | 2019 | |
| 6 | Eze/Garcia/Johnson Zuluaga(State) | 43.72 | 2015 | |
| 7 | Rodriguez/Eze /Johnson/DelRio | 43.76aw | 2014 | |
| 8 | Palomino/Lind/Wade/Panek-Kravitz | 43.78 | 2019 | |
| 9 | Levin/Aguilar/Connelly/Hurtado | 43.91 | 2025 | |
| 10 | Rodriguez/Garcia/Johnson/DelRio | 43.93 | 2014 | |
| 10 | Toyne/Meyers/Knecht/Panek-Kravitz | 43.93 | 2018 | |
| 11 | Nieto/Palomino/Cossentino/Lind | 43.98 | 2020 | |
| 12 | Audi/Scott/Krick/Ballanger/Chamberlain | 44.09e | 1998 | |
| 12 | Toyne/Meyers/Estes/Panek-Kravitz | 44.09 | 2018 | |
| 13 | Johnson/Garcia/Toyne/Zuluaga | 44.12 | 2015 | |
| 14 | Garcia/Aguilar/Dalacas/Anthony | 44.13 | 2024 | |
| 15 | Toyne/Holton/Panek-Kravitz/Zuluaga | 44.28 | 2016 | |
| 15 | Toyne/Meyers/Knecht/Panek-Kravetz | 44.28 | 2017 | |
| 16 | Meyers/Holton/Garcia/Zuluaga | 44.34 | 2016 | |
| 17 | /// (State) | 44.85 | 1999 | |
| 18 | Eze/N.Russell/A.Johnson/Rodriguez | 44.49 | 2013 | |
| 19 | Hurtado/Creech/ Garcia/Welp | 44.52 | 2023 | |
| 20 | Palomino/Knecht/Estes/Panek-Kravitz | 44.55 | 2017 | |
| 21 | Toyne/Kulak/Estes/Panek-Kravitz | 44.68 | 2018 | |
| 22 | Audi/Scott/Krick/Ballanger | 44.69 | 1998 | |
| 23 | Rodriguez/Procopio/Bayda/C.Russell | 44.74 | 2011 | |
| 24 | Seton | 44.76 | 2012 | |
| 25 | Seton | 44.78e | 2000 | |
| 26 | Meyers/Knecht/Wallace/Panek-Kravitz | 44.81 | 2017 | |
| 27 | Seton | 44.85 | 1999 | |
| 27 | Castillo/Kossler/Miranda/Castro | 44.85 | 2022 | |
| 28 | Rodriguez/Russell/Johnson/Eze | 44.86 | 2012 | |
| 29 | Castillo/Miranda/McNally/Castro | 44.88 | 2022 | |
| 30 | Castillo/DiPuccio/Miranda/Castro | 44.90 | 2022 | |
| 31 | Creech/Garcia/Welp/Pongratz | 44.94 | 2023 | |
| 32 | Aguilar/Connley/Levin/Hurtado | 44.98 | 2025 | |
| 33 | Garcia/Hurtado/Dalacas/Anthony | 45.03 | 2024 | |
| 34 | Rodriguez/Eze/A.Johnson/Del Rio | 45.05 | 2012 | |
| 35 | Russell/Fugger/A.Johnson/Del Rio | 45.12 | 2012 | |
| 36 | Seton | 45.13e | 2001 | |
| 37 | /// | 45.14 | 2015 | |
| 38 | Bayda/Procopio/Russell/Rodriguez | 45.15 | 2011 | |
| 39 | Seton | 45.19 | 2025 | |
| 40 | Colbert/McDonnell/Abernethy/Fernandez | 45.1 | 2006 | |
| 41 | Toyne/Shipley/Holton/Garcia | 45.20 | 2016 | |
| 42 | Meyers/Garcia/Johnson/Zulaga | 45.26 | 2015 | |
| 43 | Parks/McDonnell/Crowley/Koestner | 45.30 | 2007 | |
| 44 | Knecht/Estes/Panek-Kravitz/Wallace | 45.33 | 2017 | |
| 45 | Crowley/Kirkman/Karam/Gleisner | 45.34 | 2008 | |
| 46 | A.Johnson /Russel/D.Johnson/Rodriquez | 45.37 | 2013 | |
| 47 | (frosh-soph) Palomino/Knecht/Cosentino/Lind | 45.40 | 2018 | |
| 47 | Bayda/Yeskey/Del Rio/Rodriguez | 45.50 | 2012 | |
| 48 | Eze/Russel/A.Johnson/Rodriquez | 45.54 | 2013 | |
| 49 | Seton (CSHS INV) | 45.5c | 1998 | |
| 50 | Seton | 45.76 | 2006 | |
| 51 | Parks/McDonnell/Crowley/Koestner | 45.78 | 2007 | |
| 52 | Seton | 45.86 | 1995 | |
| 53 | Toyne/Wade/Knecht/Panek-Kravitz | 45.88 | 2017 | |
| 54 | Seton (State) | 45.90 | 1997 | |
| 55 | Koestner/Korte/Abarnathy/Hernandez | 45.90 | 2004 | |
| 56 | Castillo/Miranda/McNally/Kossler | 45.92 | 2022 | |
| 57 | Seton | 45.95 | 2008 | |
| 58 | A.Johnson//Del Rio/Rodriguez/Bayda | 45.98 | 2012 | |
| 59 | Seton (City) | 45.96 | 2012 | |
| 60 | Koestner/Abarnathy/Gorski/Fernandez | 45.9 | 2004 | |
