| Rank | Athlete | Mark | Year | Class |
|---|---|---|---|---|
| 1 | Lindsey Warburton | 2:22.39 | 2005 | |
| 2 | Thalia Fickett | 2:23.89 | 2024 | |
| 3 | Natalie Rosalez | 2:24.83 | 2004 | |
| 4 | Elizabeth Sericati | 2:25.30 | 2022 | SR |
| 5 | Melissa Miller | 2:28.17 | 2000 | |
| 6 | Amanda Veals | 2:29.14 | 2010 | SR |
| 7 | Carly Sandell | 2:30.96e | 2001 | |
| 8 | Vicky Taverna | 2:31.05 | 2012 | JR |
| 9 | Sarah Naldo | 2:31.65 | 2014 | SO |
| 10 | Hanna Thiele | 2:31.77 | 2025 | |
| 11 | Jordan Plichta | 2:31.88 | 2009 | |
| 12 | Natalie Brown | 2:32.01 | 2003 | |
| 13 | Christina Joslin | 2:33.41 | 2019 | FR |
| 14 | Aryn Seminara | 2:33.90e | 1995 | |
| 15 | Joanie Carosello | 2:34.06 | 2016 | SR |
| 16 | Briana Trevino | 2:34.44 | 2016 | SR |
| 17 | Siena Bujold | 2:35.48 | 2025 | SO |
| 18 | Natalie Casillas | 2:35.79 | 2026 | |
| 19 | Katie Blomberg | 2:36.01 | 2006 | |
| 20 | Brooke Huppenthal | 2:37.0c | 2009 | |
| 21 | Jessica O’Brien | 2:37.51e | 1998 | |
| 22 | Ginger Howard | 2:37.59e | 2003 | |
| 23 | Stephanie Richard | 2:38.0c | 1988 | |
| 24 | Beth Lopez | 2:38.8 | 2015 | |
| 25 | Kylie VanArsdale | 2:38.93 | 2015 | JR |
| 26 | Ashley Oakes | 2:39.46e | 2003 | |
| 27 | Coleen Tighe | 2:41.17 | 2007 | |
| 28 | Megan Burke | 2:41.69 | 2011 | SO |
| 29 | Kim Thomas | 2:42.64e | 1996 | |
| 30 | Alayn Seminara | 2:44.54e | 1997 | |
| 31 | Danielle Peterson | 2:44.55 | 2016 | JR |
| 32 | Halle Brady | 2:44.66 | 2012 | SO |
| 33 | Alex Gutting | 2:44.99 | 2003 | |
| 34 | Bella Pistilli | 2:45.01 | 2024 | FR |
| 35 | Mo Howell | 2:45.1c | 2004 | |
| 36 | Danielle Peterson | 2:45.40 | 2017 | SR |
| 37 | Lauran Harrigan | 2:45.83 | 2008 |